Long non-coding RNA SNHG1 activates HOXA1 expression via sponging miR-193a-5p in breast cancer progression

Abstract

Breast cancer is the leading cause of cancer death in women worldwide. Long non-coding RNA small nucleolar RNA host gene 1 (<i>SNHG1</i>) has been reported to be involved in human diseases, including cancer. Here, we found that <i>SNHG1</i> expression was significantly upregulated in human breast cancer tissues and cell lines. We explored the function of <i>SNHG1</i> in breast cancer cells using <i>in vitro</i> and <i>in vivo</i> experiments and found that <i>SNHG1</i> promotes breast cancer metastasis and proliferation. The potential molecular mechanism of <i>SNHG1</i> in breast cancer cells may involve <i>SNHG1</i> acting as a sponge of <i>miR-193a-5p</i> to activate the expression of the oncogene <i>HOXA1</i>. In summary, our study reveals a novel <i>SNHG1</i>/<i>miR-193a-5p/HOXA1</i> competing endogenous RNA regulatory pathway in breast cancer progression and may provide new strategies for breast cancer therapy.