A First Step to a Biomarker of Curative Surgery in Colorectal Cancer by Liquid Biopsy of Methylated Septin 9 Gene

Abstract

Our study shows that circulating hypermethylated <i>SEPT9</i> is a specific colorectal cancer biomarker. This hypermethylated <i>SEPT9</i> DNA disappears around three months after surgery and that circulating hypermethylated <i>SEPT9</i> may be the first noninvasive marker for postsurgical diagnosis; this conclusion must be confirmed with a more significant number of patients.