First‐in‐human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G‐protein‐biased sphingosine‐1 phosphate receptor‐1 agonist for endothelial protection - Concepedia

Concepedia

Publication | Open Access

First‐in‐human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G‐protein‐biased sphingosine‐1 phosphate receptor‐1 agonist for endothelial protection

DOI Full Paper Access

14

Citations

26

References

2020

Year

L. Bergougnan, Sara Armani, Georg Golor, Agnes Tardat, Olivier Vitse, Fabrice Hurbin, Michel Scemama, Franck Poitiers, David Radzik, Christophe Gaudin,

British Journal of Clinical Pharmacology

Abstract

SAR247799 is suitable for exploring the biological role of endothelial S1P<sub>1</sub> activation without causing receptor desensitization.

References

	Year	Citations

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