Sirtuin 3‐mediated deacetylation of acyl‐<scp>CoA</scp> synthetase family member 3 by protocatechuic acid attenuates non‐alcoholic fatty liver disease

Abstract

SIRT3-mediated ACSF3 deacetylation is a novel molecular mechanism in NAFLD therapy and protocatechuic acid confers protection against high-fat diet- and palmitic acid-induced hepatic fatty acid metabolism disorder through the SIRT3/ACSF3 pathway.