K ₂ CO ₃ ‐Promoted Ring‐Opening/Cyclization Reactions of Multi‐substituted Donor‐Acceptor Cyclopropanes with Thiourea: Access to 2‐Amino‐4,6‐diarylnicotinonitrile Derivatives

Abstract

Abstract The ring‐opening/cyclization reactions of substituted 2‐acyl‐3‐arylcyclopropane‐1,1‐dicarbonitriles with thiourea promoted by K 2 CO 3 were investigated successfully. Using the reaction, the desired 2‐amino‐4,6‐diarylnicotinonitrile derivatives were obtained in good to excellent yields. This work provides a new strategy for the synthesis of 2‐amino‐4,6‐diarylnicotinonitrile derivatives.