The MRI Features and Prognosis of Gliomas Associated With IDH1 Mutation: A Single Center Study in Southwest China

Abstract

<b>Purpose:</b> To investigate the associations of MRI radiological features and prognosis of glioma with the status of isocitrate dehydrogenase 1 (IDH1). <b>Material and Methods:</b> A total of 116 patients with gliomas were retrospectively recruited from January 2013 to December 2015. All patients were undergone routine MRI (T1WI, T2WI, T2-FLAIR) scanning and contrast-enhanced MRI T1WI before surgery. The following imaging features were included: tumor location, diameter, the pattern of growth, boundary, the degree of enhancement, mass effect, edema, cross the middle line, under the ependyma. χ² and Fisher's exact probability tests were used to determine the significance of associations between MRI features and IDH1 mutation of glioma. The survival distributions were estimated using Kaplan-Meier compared by Log-rank test. Univariate and multivariate analyses were performed using Cox regression. <b>Results:</b> Gliomas with IDH1 mutant were significantly more likely to exhibit homogeneous signal intensity (<i>p</i> = 0.009) on non-contrast MRI protocols and less contrast enhancement (<i>p</i> = 0.000) on contrast enhanced T1WI. IDH1 mutant type glioma was more inclined to cross the midline to invade contralateral hemisphere (<i>p</i> = 0.001). The overall survival between IDH1 mutated and wild type glioma were significantly different (<i>p</i> = 0.000), age ≤ 40 (<i>p</i> = 0.003), KPS scores > 80 before operation (<i>p</i> = 0.000) and low grade glioma (<i>p</i> = 0.000). <b>Conclusions:</b> Our results suggest IDH1 mutant in gliomas is more likely to exhibit homogeneous signal intensity, less contrast enhancement and more inclined to cross the midline. Patients with IDH1 mutated, age ≤ 40, KPS scores > 80 before operation and low-grade glioma may have a longer life and better prognosis.