<p>Silencing <em>TCF4</em> Sensitizes Melanoma Cells to Vemurafenib Through Inhibiting <em>GLUT3</em>-Mediated Glycolysis</p>

Abstract

Our study demonstrates that <i>TCF4</i> downregulation sensitizes melanoma cells to vemurafenib through inhibiting <i>GLUT3</i>-mediated glycolysis. These findings support <i>TCF4</i> as an oncogene and provide new mechanism by which <i>TCF4</i> confers chemotherapy resistance in melanoma.