The association between circulating levels of vitamin D and inflammatory markers in the first 2 years after colorectal cancer diagnosis

Abstract

Serum 25(OH)D₃ levels were inversely associated with the summary inflammatory <i>z</i>-score and in particular with IL6 in the years following CRC diagnosis. This is of potential clinical relevance as IL6 has an important role in chronic inflammation and is also suggested to stimulate cancer progression. Further observational studies should investigate whether a possible 25(OH)D₃-associated reduction of inflammatory mediators influences treatment efficacy and CRC recurrence.