Effectiveness and safety of dupilumab for the treatment of severe asthma in a real‐life French multi‐centre adult cohort

Clairelyne Dupin, Drifa Belhadi, Laurent Guilleminault, Anne‐Sophie Gamez, Patrick Berger, Frédéric de Blay, Philippe Bonniaud, Christophe Leroyer, Guillaume Mahay, Pierre‐Olivier Girodet,

Clinical & Experimental Allergy · 2020 · 130 citations · 14 references

Abstract

In this first real-life cohort study of predominantly steroid-dependent SA, dupilumab significantly improved asthma control and lung function and reduced oral steroids use and exacerbations rate. Despite limitations due to the retrospective study, these results are consistent with controlled trials efficacy data. Further studies are required to assess the clinical significance and long-term prognosis of sustained dupilumab-induced hypereosinophilia.

References

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