S S Korsakov Journal of Neurology and Psychiatry · 2020 · 14 citations · 6 references
MedicineOrthopaedic SurgeryOrthopedic SurgeryInflammationOrthopedicsPain MedicineAnalgesiaAnti-inflammatory PharmacologyCytokine BiologyInflammatory ProcessesJoint DiseaseOsteoarthritisAntiresorptive Therapy EffectsBone Matrix ProteinsInflammatory Cytokine EffectsInflammatory Pain BiomarkersNonsteroidal Anti-inflammatory Drug AnalgesiaNonsteroidal Anti-inflammatory Drug PharmacologyNonsteroidal Anti-inflammatory Drug UseProcollagen Iii Peptide
OBJECTIVE: To evaluate the antiresorptive-cytokine effects of chondroitin sulfate on non-specific lower back pain in patients with knee osteoarthritis (OA). MATERIALS AND METHODS: - after 60 days with the assessment of blood parameters: transforming growth factor β1 (TFR β1), interleukin (IL)-1β and IL-6, beta-Crosslaps, bone matrix formation indicator P1NP (n-terminal propeptide procollagen type 1), and determination of the level of deoxypyridinoline (DPID) in the urine. RESULTS AND CONCLUSION: <0,001), which may indicate the presence of its own antiresorptive-cytokine effect in chondroitin sulfate.
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