Photothermal modulation of human stem cells using light-responsive 2D nanomaterials

Abstract

Two-dimensional (2D) molybdenum disulfide (MoS₂) nanomaterials are an emerging class of biomaterials that are photoresponsive at near-infrared wavelengths (NIR). Here, we demonstrate the ability of 2D MoS₂ to modulate cellular functions of human stem cells through photothermal mechanisms. The interaction of MoS₂ and NIR stimulation of MoS₂ with human stem cells is investigated using whole-transcriptome sequencing (RNA-seq). Global gene expression profile of stem cells reveals significant influence of MoS₂ and NIR stimulation of MoS₂ on integrins, cellular migration, and wound healing. The combination of MoS₂ and NIR light may provide new approaches to regulate and direct these cellular functions for the purposes of regenerative medicine as well as cancer therapy.