Cytotoxic jatrophane diterpenoids from the aerial parts of <i>Euphorbia helioscopia</i>

Abstract

A phytochemical study of 80% ethanol extract from the aerial parts of <i>Euphorbia helioscopia</i> led to the isolation of three new jatrophane diterpenoids, euphoheliphanes A-C (<b>1-3</b>). Their structures were established on the basis of spectroscopic data (NMR, IR, UV, and MS). The isolated diterpenoids were tested <i>in vitro</i> for cytotoxic potentials against 6 renal cancer cell lines. As a result, compounds <b>1-3</b> exhibited some cytotoxic activities against all the tested tumor cell lines with IC₅₀ values less than 50 μM.[Formula: see text].