Arachidonic acid metabolism is elevated in<i>Mycoplasma gallisepticum</i>and<i>Escherichia coli</i>co-infection and induces LTC4 in serum as the biomarker for detecting poultry respiratory disease

Abstract

MG: <i>Mycoplasma gallisepticum;</i> E.coli: <i>Escherichia coli</i>; AA: Arachidonic acid; LTC4: Leukotriene C4; CRD: chronic respiratory diseases; KEGG: Kyoto Encyclopedia of Genes and Genomes; LTs: leukotrienes; PGs: prostaglandins; NO: nitric oxide; HIS: histamine; PCA: Principal Component Analysis; PLS-DA: Partial Least Squares Discriminant Analysis; CCU: color change unit; UPLC: ultra-performance liquid chromatography; MS: mass spectrometry; DEMs: differentially expressed metabolites; ELISA: enzyme-linked immunosorbent assay; SD: standard deviation; VIP: Variable importance in the projection.