<i>H19</i> Promotes the Gastric Carcinogenesis by Sponging <i>miR-29a-3p</i> : Evidence from lncRNA–miRNA–mRNA Network Analysis

Abstract

<b>Aim:</b> To identify novel competing endogenous RNA (ceRNA) network correlated with the prognosis of gastric cancer (GC) patients. <b>Materials & methods:</b> We systematically analyzed the aberrantly expressed genes in human GC to construct a ceRNA network by using multiple bioinformatic tools. <b>Results:</b> Aberrantly expressed mRNAs in GC were identified. By means of stepwise reverse prediction and validation from mRNA to lncRNA, a ceRNA network comprised of <i>H19, miR-29a-3p, COL3A1, COL5A2, COL1A2</i> and <i>COL4A1</i> was constructed, and all genes in the network are significantly correlated with the prognosis of GC patients. <b>Conclusion:</b> The present study successfully constructed a GC related ceRNA network, and provided potential targets for GC clinical treatment.