Overcoming underpowering: Trial simulations and a global rank end point to optimize clinical trials in children with heart disease

Subgroup analysis and other (mis)uses of baseline data in clinical trials

Susan F. Assmann, Stuart Pocock, Laura E. Enos et al. · The Lancet · 2000 · 1.2K citations

Meta-analysis, Clinical Trial Management, Statistics +9

Comparison of Shunt Types in the Norwood Procedure for Single-Ventricle Lesions

Richard G. Ohye, Lynn A. Sleeper, Lynn Mahony et al. · New England Journal of Medicine · 2010 · 899 citations · Full text

The Randomized Registry Trial — The Next Disruptive Technology in Clinical Research?

Michael S. Lauer, Ralph B. D’Agostino · New England Journal of Medicine · 2013 · 573 citations

Underlying Data Sets, New Study Design, Next Disruptive Technology +17

Carvedilol for Children and Adolescents With Heart Failure

Robert E. Shaddy, Mark M. Boucek, Daphne T. Hsu et al. · JAMA · 2007 · 559 citations

The risks and rewards of covariate adjustment in randomized trials: an assessment of 12 outcomes from 8 studies

Brennan C Kahan, Vipul Jairath, Caroline J Doré et al. · Trials · 2014 · 490 citations · Full text