Concepedia

<p>Melatonin Attenuates Anoxia/Reoxygenation Injury by Inhibiting Excessive Mitophagy Through the MT2/SIRT3/FoxO3a Signaling Pathway in H9c2 Cells</p>

Jinjing Wu, Yanli Yang, Yafen Gao, Zhao‐Qi Wang, Jun Ma

Drug Design Development and Therapy · 2020 · 80 citations · 46 references

DOIFull text

Open access

Abstract

These results indicate that melatonin protects H9c2 cells during A/R injury through suppressing excessive mitophagy by activating the MT2/SIRT3/FoxO3a pathway. Melatonin may be a useful candidate for alleviating myocardial ischemia/reperfusion (MI/R) injury in the future, and the MT2 receptor might become a therapeutic target.

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