Focal adhesion kinase (FAK) is associated with poor prognosis in urinary bladder carcinoma.

Abstract

Overexpression of FAK corelates with well established pathologic risk factors and may predict more aggressive biologic behavior in urinary bladder carcinoma. The expression patterns of FAK correlated well with the pathologic stage, disease progression, and carcinoma-specific survival. This finding may aid in identifying more biologically aggressive carcinomas and thus patients who could benefit from more intensive adjuvant therapy.