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SERUM CONCENTRATION OF α2-MACROGLOBULIN, HAPTOGLOBIN AND α1-ANTITRYPSIN IN DIABETES MELLITUS
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1967
Year
α 2ImmunologyMetabolic SyndromeRenal FunctionBioanalysisHematologyIga GlomerulonephritisChronic Kidney DiseaseHealth SciencesDiabetes ManagementSerum ConcentrationMedicineInsulin ManagementDiabetes ComplicationsUrologyDiabetesPhysiologyDiabetic Kidney DiseaseDiabetes MellitusHyperglycemiaα 1Nephrology
ABSTRACT The serum concentration of α 2 -macroglobulin and that of haptoglobin, the two main components of the electrophoretic α 2 fraction, and of α 1 -antitrypsin were studied in a series of outpatients with diabetes mellitus. In all age groups a significant increase of α 2 -macroglobulin was noted. In adults the increase showed a significant positive correlation with the duration of the disease and was accentuated in the presence of nephropathy with proteinuria. No further increase was noted in the occurrence of other vascular complications. In adult diabetics haptoglobin and α 1 -antitrypsin were significantly increased. No correlation was found between the duration of the disease and the concentration of haptoglobin or α 1 -antitrypsin. Neither haptoglobin nor α 1 -antitrypsin were increased in diabetic children. It is proposed that the concentration of α 2 -macroglobulin is more related to diabetes mellitus per se than that of haptoglobin or α 1 -antitrypsin, which are increased most in response to complications with inflammatory reaction.