Neuroprotective Effects of D‐(‐)‐Quinic Acid on Aluminum Chloride‐Induced Dementia in Rats

Abstract

D-(-)-Quinic acid (200 mg/kg and 400 mg/kg) orally administered alongside AlCl₃ rescued AChE activity and the behavioral impairments caused by aluminum. There was significant inhibition of MAO-B in D-(-)-quinic acid-treated rats. Histopathological studies in the hippocampus and cortex of the rat brain also supported that D-(-)-quinic acid markedly reduced the toxicity of AlCl₃ and preserved the normal histoarchitecture pattern of the hippocampus and cortex. These results indicate that D-(-)-quinic acid can reverse memory loss caused by aluminum intoxication by attenuating AChE activity and rescuing the deleterious effect of AlCl₃.