Cadmium induces mitophagy via AMP‐activated protein kinases activation in a PINK1/Parkin‐dependent manner in PC12 cells

Abstract

These results suggest that Cd induces mitophagy via the PINK/Parkin pathway following AMPK activation in PC12 cells. Targeting the balanced activity of AMPK/PINK1/Parkin-mediated mitophagy signalling may be a potential therapeutic approach to treat Cd-induced neurotoxicity.