Is there relationship between SARS-CoV-2 and the complement C3 and C4?

Abstract

Dear Editor The new coronavirus COVID-19 pandemic continues to affect human health worldwide seriously. The disease is spread mainly via large droplets. A lot of cases are asymptomatic, while the others are symptomatic. The main symptoms are fever, cough, shortness of breath, while anosmia, conjunctivitis, and gastroenteritis are less common. Until an effective vaccine or treatment is found, the most important means of prevention remains to be social isolation. COVID-19 patients showed lymphopenia, abnormal respiratory findings, and increased levels of plasma proinflammatory cytokines [1]. SARS-CoV-2 virus is a respiratory system attacking agent causing severe pneumonia and other vital systemic features including cardiac injury [2]. Furthermore, hematologic and coagulation abnormalities, such as elevated ferritin, D-Dimer, prolongation of prothrombin time/activated partial thromboplastin time, and thrombocytopenia are common among these patients