<p>Mechanisms of Heteroresistance and Resistance to Imipenem in <em>Pseudomonas aeruginosa</em></p>

Abstract

Down-regulation of <i>oprD</i> contributed to the resistance and heteroresistance of imipenem in our <i>P. aeruginosa</i> clinical isolates. In addition, the marginal up-regulation of efflux systems may indirectly affect imipenem resistance. Contrarily, defective <i>oprD</i> was less common in our experimental heteroresistant strains than resistant strains.