Sex-Based Differences in Response to Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke

Abstract

In this pooled analysis of rtPA in acute ischemic stroke, women benefited more than men, and the usual gender difference in outcome favoring men was not observed in the thrombolytic therapy group. For patients presenting at later time intervals, when the risks and benefits of rtPA are more finely balanced, sex may be an important variable to consider for patient selection.