Sporadic vestibular schwannoma: a molecular testing summary

Abstract

Undiagnosed schwannoma predisposition may account for a significant minority of apparently sVS cases, especially at lower presentation ages. Loss of <i>NF2</i> function is a common event in VS tumours and may represent a targetable common pathway in VS tumourigenesis. These data also support the multi-hit mechanism of <i>LZTR1</i>-associated VS tumourigenesis.