Fluorene exposure among PAH-exposed workers is associated with epigenetic markers related to lung cancer

Abstract

Chimney sweeps and creosote-exposed workers were occupationally exposed to low-molecular-weight PAHs. Increasing fluorene exposure, among chimney sweeps, was associated with lower DNA methylation of <i>F2RL3</i> and <i>AHRR</i>, markers for increased lung cancer risk. These findings warrant further investigation of fluorene exposure and toxicity.