<p>Associations Between Gestational Diabetes Mellitus Risk and Folate Status in Early Pregnancy and <em>MTHFR</em> C677T Polymorphisms in Chinese Women</p>

Abstract

Higher RBC folate, partly caused by <i>MTHFR</i> 677C→T, may be associated with increased GDM risk, even in early pregnancy. Assessing RBC folate status and appropriately supplementing folate during early pregnancy, particularly for patients with <i>MTHFR</i> 677C→T, may prevent GDM. Further studies with larger populations are warranted.