Palladium‐Catalyzed Cascade Hydrosilylation and Amino‐Methylation of Isatin Derivatives

Abstract

Abstract We demonstrate that using palladium acetate as a catalyst for reduction of DMF and isatin derivatives by hydrosilanes, a cascade hydrosilylation and amino‐methylation reaction can be realized. With DMF as a reactant and a solvent, the in‐situ generated siloxymethylamine intermediate, an adduct of DMF and hydrosilanes, smoothly participates in the successive stages, providing a serials of Si, N‐functionalized indolin‐2‐ones in moderate to good yields. This strategy exhibits high chemoselectivity toward carbonyl moieties reduction among the substrates. magnified image