Acute stress induces visceral hypersensitivity via glucocorticoid receptor–mediated membrane insertion of TRPM8: Involvement of a non‐receptor tyrosine kinase Pyk2

Abstract

Collectively, acute stress-induced VH could involve membrane-bound GR-dependent enhancement of TRPM8 function in nociceptive DRG neurons. Mechanistically, Pyk2 could act as a key mediator that coordinates multiple protein kinase signaling and triggers phosphorylation and membrane insertion of TRPM8.