The progress of circular RNAs in various tumors.

Abstract

Circular RNAs (circRNAs), a novel type of non-coding RNAs, presented as covalently closed continuous loops. Recent researches had found that circRNAs could function as microRNA sponges, regulators of gene transcription and encoding proteins. They were relatively stable and expressed widely in cytoplasm, which played important roles in carcinogenesis of cancers, such as esophageal cancer, gastric cancer, colorectal cancer, hepatocarcinoma, bladder cancer, glioma, breast cancer, osteosarcoma and so on. Furthermore, they were involved in many biological functions, like cell proliferation, drug resistance, cell cycle, invasion and metastasis. Therefore, the further studies were meaningful on the mechanism of cancers and circRNAs. In the review, we will summarize the current biogenesis of circRNAs and the roles of them in various cancers, which might be a novel biomarker and therapeutic avenue.