Resistance of Klebsiella pneumoniae Strains Carrying blaNDM–1 Gene and the Genetic Environment of blaNDM–1

Abstract

<i>bla</i> _NDM-1-containing bacteria exhibit multidrug resistance, which rapidly spreads and is transferred through efficient plasmid conjugation; the multidrug resistance of these bacteria may be determined by analyzing their drug-resistant plasmids. The presence of <i>ble</i> and <i>tnpA</i> genes suggests a possible hypothesis that <i>bla</i> _NDM-1 originates from <i>A. baumannii</i>, which is retained in <i>K. pneumoniae</i> over a long period by transposition of mobile elements.