Palladium-Catalyzed Decarboxylative<i>ortho</i>-Acylation of<i>O</i>-Methyl Ketoximes via Direct sp²C—H Bond Activation

Abstract

The palladium-catalyzed decarboxylative ortho-acylation of O-methyl ketoximes with -oxocarboxylic acids in the presence of Na 2 S 2 O 8 and Ag 2 O is demonstrated. This protocol can be applied to various O-methyl ketoximes and -oxocarboxylic acids with both electron-donating and electron-withdrawing groups with products yields up to 98%.