Trifluoromethyloxadiazoles: inhibitors of histone deacetylases for control of Asian soybean rust

Abstract

Fungal class II HDACs are potential target enzymes for the control of at least some biotrophic crop diseases, in particular Asian soybean rust. As with any novel mode-of-action, class II HDAC fungicides would offer the potential to control fungal isolates that show reduced sensitivity toward existing commercial fungicides.