Concepedia

Vidofludimus calcium, a next generation DHODH inhibitor for the Treatment of relapsing-remitting multiple sclerosis

Andreas Muehler, Evelyn Peelen, Hella Kohlhof, Manfred Gröppel, Daniel Vitt

Multiple Sclerosis and Related Disorders · 2020 · 64 citations · 23 references

DOI

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References

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Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression.

Sunil K. Manna, Bharat B. Aggarwal · PubMed · 1999 · 209 citations

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Immunosuppressive Leflunomide Metabolite (A77 1726) Blocks TNF-Dependent Nuclear Factor-κB Activation and Gene Expression

Sunil K. Manna, Bharat B. Aggarwal · The Journal of Immunology · 1999 · 187 citations · Full text

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Inhibition of JAK3 and STAT6 Tyrosine Phosphorylation by the Immunosuppressive Drug Leflunomide Leads to a Block in IgG1 Production

Karyn F. Siemasko, Anita S. Chong, Hans‐Martin Jäck et al. · The Journal of Immunology · 1998 · 173 citations · Full text

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Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide

Thomas Mattar, Kulvinder S. Kochhar, Robert Bartlett et al. · FEBS Letters · 1993 · 154 citations · Full text

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Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects

Luisa Klotz, Melanie Eschborn, Maren Lindner et al. · Science Translational Medicine · 2019 · 143 citations · Full text

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