Restoration of functional sperm production in irradiated pubertal rhesus monkeys by spermatogonial stem cell transplantation

Abstract

We confirmed that SSC transplantation can be used for restoration of fertility in male cancer survivors exposed to irradiation as a therapeutic agent. The success rate of this procedure, however, is low. The success of filling the tubules with the cell suspension, but not the GnRH-ant treatment, was related to the level of colonization by transplanted cells.