Quantitative analysis of variability in an integrated model of human ventricular electrophysiology and β-adrenergic signaling

Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.

Michael R. Bristow, Robert Ginsburg, Victor A. Umans et al. · Circulation Research · 1986 · 1.3K citations · Full text

Medicine, Cardiology, Physiology +17

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

Tom O’Hara, László Virág, András Varró et al. · PLoS Computational Biology · 2011 · 1.2K citations · Full text

Medicine, Cardiology, Physiology +17

Central Command Neurons of the Sympathetic Nervous System: Basis of the Fight-or-Flight Response

Arthur S.P Jansen, Xay Van Nguyen, Vladimir Karpitskiy et al. · Science · 1995 · 733 citations

Life Sciences, Neurobiology, Neuroscience +17

Assessment of the beta-adrenergic receptor pathway in the intact failing human heart: progressive receptor down-regulation and subsensitivity to agonist response.

Michael B. Fowler, J Laser, G L Hopkins et al. · Circulation · 1986 · 565 citations

Medicine, Cardiology, Pharmacology +14

Parameter Sensitivity Analysis in Electrophysiological Models Using Multivariable Regression

Eric A. Sobie · Biophysical Journal · 2009 · 279 citations · Full text

Life Sciences, Biomedical Engineering, Biostatistics +14