Concepedia

Optical Control of CRAC Channels Using Photoswitchable Azopyrazoles

Xingye Yang, Guolin Ma, Sisi Zheng, Xiaojun Qin, Xiang Li, Lüpei Du, Youjun Wang, Yubin Zhou, Minyong Li

Journal of the American Chemical Society · 2020 · 49 citations · 45 references

DOI

Concepts

Abstract

to alleviate thrombocytopenia and hemorrhage in a zebrafish model of Stormorken syndrome in a light-dependent manner.

References

45

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

Shenyuan L. Zhang, Ying Yu, Jack Roos et al. · Nature · 2005 · 1.4K citations · Full text

, , +12

An Expanded Palette of Genetically Encoded Ca <sup>2+</sup> Indicators

Yongxin Zhao, Satoko Araki, Jiahui Wu et al. · Science · 2011 · 1.3K citations · Full text

, , +17

Photopharmacology: Beyond Proof of Principle

Willem A. Velema, Wiktor Szymański, Ben L. Feringa · Journal of the American Chemical Society · 2014 · 1.2K citations · Full text

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STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

Chan Young Park, Paul Hoover, Franklin M. Mullins et al. · Cell · 2009 · 954 citations · Full text

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A Roadmap to Success in Photopharmacology

Johannes Broichhagen, James A. Frank, Dirk Trauner · Accounts of Chemical Research · 2015 · 739 citations

, , +12