Preprints.org · 2020 · 11 citations · 34 references
PharmacyMaterials SciencePharmaceuticsDrug DeliveryNanomaterialsPharmaceutical FormulationDrug FormulationDrug LoadingNanocompositesNanoparticle CharacterizationNanoparticle FormulationsPolymeric NanomaterialsChitosanChitosan-based NanomaterialsDrug Loading AnalysisDrug Loading EffectsFull Factorial DesignsPolymeric Nanoparticle FormulationRelease Profile CharacterizationX-ray Diffraction Analysis
The purpose of this study was to investigate the effect of chitosan (CS) and Alginate (Alg) polymers concentrations and CaCl2 concentration on metronidazole (MET) drug loading (LE), size particles and zeta potential. Nanocomposites were prepared by ionotropic pregelation method. A (21 *31 *21) *3= 36 full factorial design (FFD) was used to predict statistical equation and responses. The MET-CS-AlgNPs nanocomposites were characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, thermal gravimetric analysis, scanning electron microscope and in vitro drug release studies. All data indicated the presence of drug into MET-CS-AlgNPs nanocomposites. The release profile of MET-CS-AlgNPs nanocomposites was found to be sustained
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Design and Analysis of Experiments
John V. Grice, Douglas C. Montgomery · Technometrics · 2000 · 2.7K citations
Thermal Analysis of Chitosan Based Networks
Cypriano Galvão da Trindade Neto, J.A. Giacometti, Aldo Eloízo Job et al. · Carbohydrate Polymers · 2005 · 544 citations
Natural Sciences, Materials Engineering, Materials Science +12