Concepedia

An Ex Vivo Evaluation of Cenobamate Administered via Enteral Tubes

Louis Ferrari, Arkady Nisman, Augustin Pegan, Jordan Ursino

Drugs in R&D · 2020 · 12 citations · 4 references

DOIFull text

Open access

Abstract

The mean % LC recovery of cenobamate was within the predetermined acceptable range of 90.0-110.0%, suggesting no adhesion or adsorption of cenobamate to enteral feeding tubes. Delivery of cenobamate suspension via enteral feeding tubes may be a viable route of administration for patients who cannot swallow tablets.

References

4

Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial

Gregory L. Krauss, Pavel Klein, Christian Brandt et al. · The Lancet Neurology · 2019 · 317 citations

, , +4

Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures

Steve Chung, Jacqueline A. French, Jacek Kowalski et al. · Neurology · 2020 · 221 citations · Full text

Rivaroxaban crushed tablet suspension characteristics and relative bioavailability in healthy adults when administered orally or via nasogastric tube

Kenneth Todd Moore, Mark A. Krook, Seema Vaidyanathan et al. · Clinical Pharmacology in Drug Development · 2014 · 48 citations

Drugs via enteral feeding tubes in inpatients: dispersion analysis and safe use of dispensers

Milena Pontes Portela Beserra, Cristiani Lopes Capistrano Gonçalves de Oliveira, Mileyde Ponte Portela et al. · Nutrición Hospitalaria · 2017 · 10 citations · Full text