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Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy, Allowing Liver Regeneration and Survival Through Induction of H2‐Bl/HLA‐G

Mayumi Ishikawa, Andrew J. Brooks, Manuel A. Fernández‐Rojo, Johan Medina, Yash Chhabra, Shiro Minami, Kathryn A. Tunny, Robert G. Parton, J.P. Vivian, Jamie Rossjohn,

Hepatology · 2020 · 34 citations · 41 references

DOIFull text

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Abstract

GH induction of H2-Bl expression is crucial for reducing innate immune-mediated apoptosis and promoting survival after PHx in C57BL/6 mice. Treatment with HLA-G may lead to improved clinical outcomes following liver surgery or transplantation.

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