T₂ relaxation‐time mapping in healthy and diseased skeletal muscle using extended phase graph algorithms

Abstract

In vivo data showed a decline in T_2water for increasing fat fractions, which has important implications for clinical studies, especially in multicenter settings. We recommend using an extended phase graph-based model for fitting T_2water from MSE sequences with two-component T_2fat calibration. Moreover, we recommend including the slice flip-angle profile in the model with correction for through-plane chemical-shift displacements.