Mediators of Inflammation · 2020 · 45 citations · 39 references
Life SciencesNeurobiologyNeuroscienceMolecular NeuroscienceNeurodegenerationNeuropharmacologyAlzheimer DiseaseNeurodegeneration MechanismsNeurodegenerative DiseasesNeurodegenerative DisordersNeuroinflammationNeuroprotectionAlzheimer Disease NeuroprotectionAmyloid-beta-induced NeurotoxicityCell Viability AssaysCell Viability PreservationNeurodegenerative Disease MechanismsNeuroprotective AgentsNeuroprotective MechanismsNeuroprotective Signaling
Alzheimer’s disease (AD) is a common neurodegenerative disease. A β plays an important role in the pathogenesis of AD. Sodium butyrate (NaB) is a short-chain fatty acid salt that exerts neuroprotective effects such as anti-inflammatory, antioxidant, antiapoptotic, and cognitive improvement in central nervous system diseases. The aim of this study is to research the protective effects of NaB on neurons against A β toxicity and to uncover the underlying mechanisms. The results showed that 2 mM NaB had a significant improvement effect on A β -induced N2a cell injury, by increasing cell viability and reducing ROS to reduce injury. In addition, by acting on the GPR109A receptor, NaB regulates the expression of AD-related genes such as APP, NEP, and BDNF. Therefore, NaB protects N2a cells from A β -induced cell damage through activating GPR109A, which provides an innovative idea for the treatment of AD.
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Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Yukihiro Furusawa, Yuuki Obata, Shinji Fukuda et al. · Nature · 2013 · 5.3K citations