Photo‐Mediated Decarboxylative Cross Coupling of Quinoxalin‐2(1<i>H</i>)‐ones with Aliphatic Carboxylic Acids in Aqueous Solution: Synthesis of Alkylated Quinoxalin‐2(1<i>H</i>)‐ones and Preliminary Antifungal Evaluation Against <i>Magnaporthe Grisea</i>

Abstract

Blue light: A decarboxylative-catalyzed Minisci-type cross coupling reaction of quinoxalin-2(1H)-ones with aliphatic carboxylic acids using iridium as photocatalyst is described herein. Varieties of quinoxalin-2(1H)-ones could be successfully converted into the alkylated quinoxalin-2(1H)-one motifs. The reaction has been successfully applied to the late stage functionalization carboxylic acid-containing bioactive molecules, and a mechanistic study indicates a radical mechanism. Moreover, preliminary antibacterial evaluation against Magnaporthe grisea showed a promising inhibitory rate. The authors declare no conflict of interest. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.