Concepedia

Publication | Closed Access

Silencing HMGB1 expression inhibits adriamycin's heart toxicity via TLR4 dependent manner through MAPK signal transduction.

15

Citations

0

References

2020

Year

Eylem Taşkın, Celal Güven, Salih Tunç Kaya, Melda Sarıman, Zeliha Emrence, Sema Sırma Ekmekçi, Yusuf Sevgiler, Handan Akçakaya
PubMed

Abstract

Inhibition of HMGB1 might prevent the lose of the cardiac cell by inhibition of apoptotic pathway, therefore HMGB1 plays an essential role as amplifying on ADR toxicity on the heart by TLR4.