Proceedings of the National Academy of Sciences · 2020 · 17 citations · 34 references
Life SciencesCell BiologyImmunologyAutoimmunityImmunoregulationInflammationAutoimmune RegulationB Cell BiologyB Cell RegulationB-cell ResponsesHumoral ImmunityNatural Killer Cell BiologyAutoreactive B Cell ActivationAutoreactive B Cell ResponsesB Cell-mediated ImmunityB-cell Mediated ImmunityInflammatory Cytokine ProductionInflammatory Cytokine SecretionProinflammatory MediatorsRegulatory B Cell Responses
Significance i NKT cells can both provide help and inhibit B cell responses. Our data show that when i NKT cells are activated with the glycolipid agonist αGalCer together with the inflammatory cytokine IL-18, they switch from regulating autoreactive B cells to promoting their expansion. As a consequence, autoreactive B cell responses remain unchecked by i NKT cells. The glycolipid αGalCer has been shown to have promising effects when administered as an adjuvant to achieve a better response to vaccines, as an antitumor agent, as well as in the regulation of autoimmunity. Our results highlight a facet of αGalCer-mediated i NKT cell activation in the context of inflammation and have broad implications for understanding the regulation of autoimmunity and use of αGalCer in therapy.
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CD1d-Restricted and TCR-Mediated Activation of V <sub>α</sub> 14 NKT Cells by Glycosylceramides
Tetsu Kawano, Junqing Cui, Yasuhiko Koezuka et al. · Science · 1997 · 2.4K citations
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
Jochen Mattner, Kristin L. DeBord, Nahed Ismail et al. · Nature · 2005 · 1.1K citations