A Solid-State Support for Separating Astatine-211 from Bismuth

Abstract

Increasing access to the short-lived α-emitting radionuclide astatine-211 (²¹¹At) has the potential to advance targeted α-therapeutic treatment of disease and to solve challenges facing the medical community. For example, there are numerous technical needs associated with advancing the use of ²¹¹At in targeted α-therapy, e.g., improving ²¹¹At chelates, developing more effective ²¹¹At targeting, and characterizing <i>in vivo</i> ²¹¹At behavior. There is an insufficient understanding of astatine chemistry to support these efforts. The chemistry of astatine is one of the least developed of all elements on the periodic table, owing to its limited supply and short half-life. Increasing access to ²¹¹At could help address these issues and advance understanding of ²¹¹At chemistry in general. We contribute here an extraction chromatographic processing method that simplifies ²¹¹At production in terms of purification. It utilizes the commercially available Pre-Filter resin to rapidly (<1.5 h) isolate ²¹¹At from irradiated bismuth targets (Bi decontamination factors ≥876 000), in reasonable yield (68-55%) and in a form that is compatible for subsequent <i>in vivo</i> study. We are excited about the potential of this procedure to address ²¹¹At supply and processing/purification problems.