Simultaneous Detection of 4-Aminophenol and Paracetamol Using a Glassy Carbon Electrode Modified with Graphene Oxide, TiO ₂ and Gold Nanoparticles

Abstract

A novel highly sensitive nanoelectrochemical sensor was prepared using graphene oxide/titanium dioxide/gold nanoparticles composites (GT@AuNPs) modified glassy carbon electrode (GCE) to measure paracetamol (PA) and 4-aminophenol (4-AP) simultaneously. It can be found that PA and 4-AP could be completely separated on the GT@AuNPs/GCE using cyclic voltammetry and differential pulse voltammetry technique. Under the best conditions, the linear responses for PA from 0.10 to 300.00 μ M with the detection limits of 0.78 nM. And the linear responses for 4-AP from 0.10 to 150.00 μ M with the detection limits of 2.36 nM. This sensor can be used to detect acetaminophen in pharmaceutical formulations with satisfactory results, indicating that the electrochemical sensor has potential application value.