Microporous Organic Nanoparticles Anchoring CeO₂ Materials: Reduced Toxicity and Efficient Reactive Oxygen Species‐Scavenging for Regenerative Wound Healing

Abstract

Abstract This work shows that microporous organic polymer can be applied to the engineering of CeO 2 ‐based antioxidant nanomaterials for in vivo regenerative wound healing. Whilst nanoparticulate CeO 2 has shown excellent redox quenching of reactive oxygen species (ROS) because it is rich in oxygen defects and Ce 3+ species, it has a strong tendency to form aggregates because it is a kinetic intermediate of bulk materials. Anchoring of nanoparticulate CeO 2 on suitable supports can be an efficient anti‐aggregation strategy. In this work, CeO 2 nanoparticles were immobilized on microporous organic nanoparticles (MONPs) to form MONP@CeO 2 nanocomposites. Compared to CeO 2 materials, the MONP@CeO 2 nanocomposites showed not only efficient ROS scavenging in in vivo regenerative wound healing but also reduced cytotoxicity in in vitro cell studies, due to the efficient distribution and dilution effect of CeO 2 nanomaterials.