Does the conventional dosage of linezolid necessitate therapeutic drug monitoring?—Experience from a prospective observational study

Abstract

Our results suggest that the pharmacodynamic range of linezolid <i>C</i> _min can be defined as 2-8 mg/L for the Chinese population. Renal function partially accounts for the inter-interindividual variability of exposure. The application of TDM might be especially valuable in optimizing linezolid exposure in the majority of patients to avoid therapeutic failure and/or dose-dependent adverse reactions.