Organic Letters · 2020 · 50 citations · 21 references
Natural SciencesCancer BiologyMedicinal ChemistryBiophysical ChemistryComputational ChemistryMolecular ImagingCellular ImagingFluorescence ImagingFluorescence SpectroscopyMolecular Imaging In OncologyMolecular Probe DevelopmentPhotophysics Of Fluorescent ProbesBoron ChemistryFluorescent Probe DesignFluorescent ProbesFluorophore DesignFluorophore PhotophysicsMolecular Imaging Probe DesignRational DesignStokes Shift
The rational design of a rigid π-extended ligand, suitable for the formation of four-coordinate boron complexes, has led to the synthesis of the fused hexacyclic structure of carbazolo[2,1-c]phenanthridine. The photophysical characterization of the novel fluorophore revealed a significant Stokes shift whose intramolecular charge transfer origin has been corroborated by computational calculations. The usefulness of the reported N,N-difluoroboryl complex as fluorescent probe with large Stokes shift has been demonstrated for cancer cells imaging.
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