Dynamic Changes in the Global Transcriptome and MicroRNAome Reveal Complex miRNA-mRNA Regulation in Early Stages of the Bi-Directional Development of Echinococcus granulosus Protoscoleces

Abstract

The early stages of bi-directional development in <i>E. granulosus</i> PSCs are controlled by miRNAs and genes likely associated with nervous system development and carbohydrate metabolic process. ATP-dependent transporter genes are associated with cystic development. These results may be important for exploring the mechanisms underlying early development in <i>E. granulosus</i> providing novel information that can be used to discover new therapeutics for controlling cystic echinococcosis.